The CLEAR Study

Overview

Do you have a history of Heart Disease and are unable to tolerate statins?

Synexus is looking for volunteers to take part in a research study for Heart Disease. Heart Disease describes a range of conditions that affect your heart. The objective of the research study is to evaluate the effects of an investigational medication to reduce the risk of major adverse cardiovascular events in individuals with, or at high risk of developing heart disease who have been unsuccessful on statin therapy due to side effects. Current statin therapy includes Simvastatin, Rosuvastatin and Atorvastatin. Statin intolerance is described as the inability to tolerate statins due to side effects (e.g. severe leg cramp) that resolved when you stopped taking the statin.

You may be at risk of heart disease if you have:

  • Had a heart attack
  • Type 1 or Type 2 Diabetes (Men older than 65 and women older than 60 years of age)
  • High cholesterol
  • Had a coronary artery bypass
  • Peripheral Arterial Disease
Age
Gender
Condition
18+
Male and Female
High cholesterol Statin intolerant with heart disease or high risk of heart disease

This study has been approved by the South African Health Products Regulatory Authority on 17 September 2018

Pharma Ethics approval dated  17 August 2018     (Ref No: 17011552

UP HREC approval dated 6 November 20148        (Ref No: 2018-01442)

Under Protection of Personal Information Act 2013, Synexus Clinical Research South Africa (Pty) Limited, is responsible for how your information is collected, used and disclosed.

Our Latest Campaign

Recruiting at the following locations

 
Location
 
Watermeyer Clinical Research Centre: Pretoria
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Helderberg Clinical Research Centre: Somerset West
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Synexus Affiliate Site: Port Elizabeth
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Synexus Affiliate Site: Bloemfontein
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Synexus Affiliate Site: University of Pretoria
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Synexus Affiliate Site: Kempton Park
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Am I eligible for this study?

To find out, please answer yes or no to the following questions.

Yes   /   No
Yes   /   No
1

I am aged 18+

 
2

I have heart disease OR I am at risk of developing heart disease

 
3

I have been unsuccessful on statin therapy

 
 

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